IndraLab

Statements

STAMBP activates MC1R. 16 / 16
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"Both mc1r and mc4r are activated by α-MSH and are involved in the control of the pigmentation and the modulation of food intake, respectively xref xref xref ."
28378841
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"The activation of MC1R by its ligand α-MSH or adrenocorticotropic hormone (ACTH) leads to an increase in adenylyl cyclase, which in turn upregulates intracellular cAMP levels [ xref , xref ]."
28241436
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"The MC1R is activated by α-MSH and antagonized by agouti signaling protein (ASIP)."
19461972
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"In both cases, knock-down of AgRP2 xref would be expected to increase MC1R activation by α-MSH, leading to the dispersion of melanosomes and decreased camouflage capability."
28317906
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"The activity of MITF is positively regulated by signaling downstream of the MC1R, which are in turn activated by α-MSH produced by UV-irradiated keratinocytes xref ."
30281145
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"MC1R activation by the α-MSH produced in keratinocytes results in stimulation of synthesis of photoprotective eumelanin (brown-black pigment) in melanocytes."
30281145
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"We show that activation of the MC1R by α-MSH contributes to phosphorylation of p53 on serine 15, a known requirement for stabilization and activation of p53, a major sensor of DNA damage."
22622028
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"ACTH can activate all five receptor subtypes; of the melanocortins, only ACTH activates MC2R; ACTH as well as α-MSH, β-MSH and γ-MSH activate MC1R, MC3R, MC4R and MC5R, although with varying affinities."
28805746
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"Activation of MC1R by α-MSH or ACTH increases cAMP synthesis which indirectly induces a switch from the production of pheomelanin to eumelanin synthesis [ xref ] ( xref )."
27428965
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"In macrophages, α-MSH activates MC1R and inhibits lipopolysaccharide (LPS)-induced nuclear factor κB (NF-κB) activation xref ."
23457491
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"Additionally, activation of MC1R by α-MSH regulates intracellular redox status by up regulating the expression of antioxidant genes, including heme oxygenase-1 (HO-1), ferritin, and peroxiredoxin-1 ( xref ; xref )."
24573173
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"ACTH (1–39) or α-MSH can activate MC1R, MC3R, MC4R, and MC5R ( xref ), but MC2R can only be activated by ACTH and not by α-MSH or other analogs ( xref )."
28228747
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"MC1R activation by α-MSH triggers an increase in cAMP levels within the melanocytes, which increase transcription of microphthalmia-associated transcription factor (MITF) via CREB/ATF1."
24759085
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"Interestingly, brief treatment with the MC1R antagonists ASIP or HBD3 inhibited activation of the MC1R by α-MSH, possibly due to receptor desensitization."
25017567
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"POMC is the precursor of α-MSH, which activates the melanocortin 1 receptor (MC1R) and induces melanin products [ xref , xref ]."
18814047
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"Α-MSH activates putative cell surface receptor MC1R and stimulates melanogenesis and proliferation of human melanocytes."
28367103