IndraLab

Statements

reach
"IC (50) for amitriptyline block of HERG current was progressively decreased according to depolarization : IC (50) values at -30, -10, +10 and +30 mV were 23.0, 8.71, 5.96 and 4.66 microM, respectively."
10742304
reach
"The decrease became more pronounced at more positive potential, suggesting that the block of HERG by amitriptyline is voltage dependent."
10742304
reach
"For example, amitriptyline, imipramine, and doxepin block the HERG channel with the IC 50 s of 10 muM, 3.4 muM, and 6.5 muM, respectively (Cavalli et al., 2002; Duncan et al., 2007)."
18191158
reach
"Amitriptyline, quinidine, compound A, fluoxetine and imipramine inhibited hERG with IC (50) s (paired values denote constantly cultured and frozen, respectively) of 4.8 +/-0.4 and 5.1 +/-0.4, 1.4 +/-0.1 and 1.1 +/-0.1, 24.4 +/-2.4 and 21.9 +/-1.8, 2.1 +/-0.4 and 2.1 +/-0.1, 5.2 +/-0.4 and 4.0 +/-0.2 muM."
21996251
reach
"Block of HERG by amitriptyline was use dependent : exhibiting a much faster block at higher activation frequency."
10742304