IndraLab

Statements

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"Block of HERG by amitriptyline was use dependent : exhibiting a much faster block at higher activation frequency."
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"For example, amitriptyline was demonstrated to inhibit cardiac HERG channels with a considerably higher affinity as compared to duloxetine ( Jo et al., 2000; Fischer et al., 2013 )."
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"For example, amitriptyline, imipramine, and doxepin block the HERG channel with the IC 50 s of 10 muM, 3.4 muM, and 6.5 muM, respectively (Cavalli et al., 2002; Duncan et al., 2007)."
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"The decrease became more pronounced at more positive potential, suggesting that the block of HERG by amitriptyline is voltage dependent."
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"IC (50) for amitriptyline block of HERG current was progressively decreased according to depolarization : IC (50) values at -30, -10, +10 and +30 mV were 23.0, 8.71, 5.96 and 4.66 microM, respectively."
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