IndraLab

Statements


USP4 deubiquitinates TGFBR. 3 / 3
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"MicroRNA 27b (miR-27b) was identified as an inhibitor of ubiquitin-specific peptidase 4 (USP4), deubiquitylating TGF-beta receptor 1 (TbetaRI), downstream from CB2."

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"The authors further go on to show that USP4 was able to deubiquitylate the TGF-beta receptor I (TbetaRI) directly and rescue it from proteasome mediated degradation."

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"It has been known that the TGF-β receptors can be deubiquitinated and stabilized by USP4, USP15 and USP11 [[18], [19], [20]]."