IndraLab

Statements

USP19 activates BECN1. 4 / 5
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"Beclin-1 stabilization is also promoted by USP19 and ataxin 3, which specifically removes K11- and K48-ubiquitin chain from Belcin-1, respectively [38, 39]."
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"Moreover, BECLIN-1 stability is increased by USP19, which counteracts Lys11-linked ubiquitination at lysine 437 [70] ."
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"USP19-mediated BECLIN-1 stabilization regulates not only the autophagy response to nutrient starvation but also the ability of BECLIN-1 to restrict innate immunity by inhibiting the RIG-I/MAVS/TBK1/IR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To check how C2-FFL, Beclin-1 early balance, and USP19 early balance modulated the positive rate of Beclin-1, we implemented the computational approach to abolish C2-FFL, downregulate Beclin-1 early b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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