IndraLab

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"For example, CSN6, a component of the COP9 signalosome, positively regulate E3 ubiquitin ligases."

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"31 Our data indicates that CSN6 enhances ubiquitin‐mediated degradation of FOXO4 through K48 link ubiquitination, thereby downregulating FOXO4.2.3 COP1 Is Involved in CSN6-Mediated Ubiquitination of FOXO4."