IndraLab

Statements


EGF phosphorylates EGFR on T693. 2 / 2
| 2

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"In concert with the findings in XREF_FIG, these data strongly suggest that the ability of EGF to activate ERKs and thereby cause phosphorylation of EGFR 669 T serves to dampen the degree of receptor kinase activation that ensues."

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"The graphical display of these data (XREF_FIG) indicates that blockade of ERK dependent phosphorylation of threonine 669 of EGFR (either pharmacologically or mutagenetically) in response to EGF leads to statistically-significantly increased EGF induced EGFR ubiquitination."