IndraLab

Statements

Ethanol inhibits NFKBIA. 5 / 5
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"Studies exploring the potential mechanism by which ethanol suppresses endothelial cell activation revealed that ethanol blocked NF-kappaB nuclear entry in an IkappaBalpha dependent manner."
15528377
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"These results suggest that while acute alcohol induced IkappaBalpha degradation could be independent of IKK kinase, chronic alcohol induced IkappaBalpha degradation is dependent on IKK kinase activity."
19561104
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"EtOH degrades I-kappaBalpha, distributes NF-kappaB to the cell nucleus, and activates NF-kappaB protein subunits."
17869053
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"In contrast, ethanol inhibited the KA- but not the QA induced degradation of IkappaB-alpha and the ensuing DNA fragmentation and loss of striatal GABAergic neurons."
10719066
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"These new data suggest that inhibition of alcohol inducible degradation of IKB-alpha by TPKC can prevent much of the adverse microvascular actions of ethanol in the intact rat brain."
12431766