IndraLab

Statements

CD274 inhibits COPS5. 5 / 5
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"Berberine decreases the expression of PD-L1 and promotes antitumor immunity through inhibiting Jab1/CSN5 activity ."
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"Additionally, another study by Liu et al (25) previously revealed that berberine can reduce PD-L1 expression levels in non-small cell lung cancer cells and promote antitumor immunity, thus inhibiting the deubiquitination activity of CSN5 and served as an immune checkpoint inhibitor."
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"Thus, stabilization of PD-L1 by inhibiting NF-kB/CSN5 is a potential strategy to treat cancer-associated inflammation."
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"Disrupting the MPN domain of CSN5 affected CSN5 mediated PD-L1 stabilization and deubiquitination XREF_BIBR."
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"Taken together, promoting PD-L1 ubiquitination via inactivating CSN5 along with inhibiting PD-L1 palmitoylation via suppressing FASN/DHHC5 axis contributed to DHA-induced PD-L1 degradation.Accumulatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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