IndraLab

Statements

Probucol increases the amount of KCNH2. 3 / 3
| 3
reach
"In hERG expressing HEK cells, overexpression of Cav1 enhanced, whereas knockdown of Cav1 impeded, probucol induced reduction of mature hERG channels."
21278233
reach
"Although diverse compounds reduce the hERG current (I (hERG)) by blocking the channel, probucol, a cholesterol lowering drug that causes LQTS, reduces I (hERG) by decreasing plasma-membrane hERG protein expression."
21278233
reach
"Furthermore, the Canadian study also found that the LDL cholesterol could efficiently impede the probucol effects by preventing probucol-induced reduction of the hERG current in hERG-expressing HEK cells (57)."
34483996