IndraLab

Statements

USP22 increases the amount of ISG. 4 / 4
| 4
reach
"Interestingly, 49 USP22 controls basal and 2'3'-cGAMP-induced STING activation and loss of STING 50 reversed STAT activation and ISG and IFN-λ expression."
| DOI
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"USP22 controls basal and 2′3′-cGAMP-induced STING ubiquitination, phosphorylation, and activation, and combined loss of USP22 and STING rescues ISG expression, STAT signaling, and IFN-λ production."
35933402
reach
"Since type III IFN-induced target genes largely overlap with genes regulated by type I IFNs [64, 65], type III IFN is likely the main IFN contributing to USP22-dependent induction of ISG expression and STAT1 activation."
35933402
reach
"Interestingly, USP22 controls basal and 2'3'-cGAMP-induced STING activation and loss of STING reversed STAT activation and ISG and IFN-lambda expression."
35933402