IndraLab

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"Reversely, overexpression of CYLD could promote cell apoptosis, whereas inhibiting cell proliferation and antibody production."
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"Here we show that genetic deficiency of Cyld, a recently identified deubiquitinating enzyme, attenuates the early wave of germ cell apoptosis and causes impaired spermatogenesis in mice."
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"CYLD (C/S) tumors are also characterized by their elevated proliferation rate and decreased apoptosis."
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"Ablation of CYLD, NFKBIA, TRAF2, or TRAF3 induces hyperactivation of the canonical and/or noncanonical NF-kappaB pathways and subsequently diminishes CC-122-induced apoptosis in 5 of 6 DLBCL cell lines."
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"This was demonstrated by the findings that knockdown of CYLD resulted in upregulation of RIPK1 that was associated with enhancement in K63 linked polyubiquitination of the protein and that co-knockdown of RIPK1 diminished CYLD knockdown induced apoptosis in sensitive cells."
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"Furthermore, we uncovered a dual function of CYLD in the pathogenesis of ECM : (i) CYLD impaired activation of PKC-theta and NF-kappaB in CD8 + T cells and (ii) CYLD promoted apoptosis of endothelial cells, thereby augmenting brain pathology and preventing survival during ECM."
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"Since the proapoptotic function of RIPK1 can be prevented by phosphorylation of Ser320 or Ser25 XREF_BIBR, we introduced the RIPK1 mutant with Ser320 or Ser25 constitutively phosphorylated into Mel-CV and ME1007 cells to test whether it impinges on apoptosis induced by silencing of CYLD."
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"A previous study reported that CYLD inhibits cell proliferation and apoptosis resistance in triple negative breast cancer."
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"As Fas associated protein with death domain (FADD), cellular inhibitor of apoptosis 1 (cIAP1), and cIAP2 are all known to regulate RIPK1 mediated apoptosis XREF_BIBR, we compared the expression levels of FADD, cIAP1, and cIAP2 between Mel-FH and Mel-CV cells that displayed different sensitivity to apoptosis induced by silencing of CYLD."
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"To our surprise, amputation induced apoptosis was increased by RNAi of tak1 or p38-1, and decreased by RNAi of cyld-1 (XREF_FIG)."
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"The mechanism responsible for apoptosis induced by CYLD knockdown in sensitive melanoma cells (Mel-CV and ME1007) appeared to be upregulation of RIPK1."
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"Previous studies have also revealed that CYLD suppression leads to decreased apoptosis and increased proliferation by activating NF-κB [23, 65]."
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"But in OCI-Ly10R cells, BTK inhibitor PCI-32765 but not rituximab could reduce CYLD phosphorylation and induce apoptosis."
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"Cointroduction of CYLD or RIPK1 siRNA abolished apoptosis induced by introduction of miR-99b-3p mimics (XREF_FIG), confirming that downregulation of CYLD and subsequent upregulation of RIPK1 are responsible for induction of apoptosis by the mimics."
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"Liver specific deletion of CYLD exon9 (CYLD lox and lox / ALFP-Cre) induces spontaneous apoptosis of periportal hepatocyte, and subsequent HSC and Kupffer cell activation, thereby triggering fibrosis, inflammation, and TNFalpha production [XREF_BIBR, XREF_BIBR]."
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"LEF1 mediated inhibition of CYLD expression is abolished upon selenite treatment to trigger apoptosis."
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"The results showed that the expression of either of the mutants attenuated apoptosis in Mel-CV and ME1007 cells when CYLD was silenced (XREF_FIG), further consolidating the role of RIPK1 in apoptosis induced by silencing of CYLD in melanoma cells."
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"Mechanistic investigations demonstrated that induction of apoptosis by CYLD knockdown was caused by upregulation of receptor-interacting protein kinase 1 ( RIPK1 ) that was associated with elevated K63-linked polyubiquitination of the protein , indicating that CYLD is critical for controlling RIPK1 expression in these cells ."
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"Flow cytometry further revealed that CYLD siRNAs inhibited both early and late apoptosis induced by noscapine in CCRF-CEM cells."
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"CYLD and cellular inhibitors of apoptosis (cIAPs) are involved in CD40 mediated cell death."
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"As shown in XREF_FIG, upon selenite treatment, cIAPs were degraded, and CYLD transcription was upregulated, causing degradation of RIP1 K63 ubiquitin chains and subsequent DISC formation, caspase-8 activation and apoptosis."
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"CYLD siRNAs inhibit the ability of noscapine to induce mitotic arrest and apoptosis in leukemia cell lines."
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"Knocking-down CYLD reversed apoptosis which was induced by BTKis."
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"Moreover, CYLD deficiency also diminishes CEP-1 and p53-dependent DNA damage induced germ cell apoptosis in the nematode Caenorhabditis elegans."
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