IndraLab

Statements

USP18 activates KRAS. 5 / 5
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"Since in vitro data revealed USP18 knockdown decreased KRAS protein stability it was sought to learn if Usp18 loss (XREF_SUPPLEMENTARY) affected lung cancer formation in the Kras driven mouse model."
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"Using the protein synthesis inhibitor cycloheximide (CHX), USP18 knockdown significantly reduced the half-life of KRAS, but gain of USP18 expression significantly increased its stability."
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"Loss of USP18 Reduces Tumorigenicity of Kras driven Lung Cancers in Mice."
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"Repression of USP18 not only decreased KRAS protein stability, but also conferred KRAS mislocalization from the plasma membrane to the endomembrane compartment."
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"Using the protein synthesis inhibitor cycloheximide, USP18 knockdown significantly reduced the half-life of KRAS, but gain of USP18 expression significantly increased its stability."
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