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SMURF1 inhibits USP5. 2 / 2
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"Taken together, our results demonstrated that Smurf1 could promote USP5 degradation through increasing USP5 ubiquitination.Tumor necrosis factor alpha (TNF-alpha) is a central mediator of the inflamma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Because the ubiquitin ligase activity of Smurf1 was required for down-regulation of USP5 protein levels, we next sought to determine whether USP5 degradation mediated by Smurf1 is a consequence of ubi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"