IndraLab

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"Accordingly, USP22 downregulation also attenuated cerebral I/R-induced oxidative stress, inflammation, and cell apoptosis in mice, thereby reducing nerve injury and neurological dysfunction [20]."
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"Thus, we infer that the possible mechanism is that in the early stage of inflammation, USP22 reduces the level of cellular inflammation through compensatory cytoplasmic translocation, and when the inflammatory stimulus is prolonged, USP22 is in a state of loss of compensation, its expression decreases markedly, and the cell undergoes a strong inflammation."
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"Overexpression of USP22 reversed LPS-induced cellular inflammation, attenuated decidualization, and inhibited ferroptosis."
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"USP22 in macrophages promotes LRR and PYD structural domain protein 3 (NLRP3) degradation and attenuates inflammation through autophagy-associated 5 homolog (ATG5)-mediated autophagy ."
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"In addition, USP22/SIRT1-regulated mitochondrial respiration can affect liver steatosis, and the silencing of USP22 in diabetic rats confers a similar protective effect against high glucose-induced ap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Addition of USP22 reduces Ang II-induced cardiac inflammation and fibrosis."
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"A previous study showed that USP22 deficiency in macrophages significantly promotes alum-induced peritoneal inflammation ."
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"Overexpression of USP22 in macrophages inhibits foam cell formation, inflammation, and macrophage apoptosis."
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"The knockout of Usp22 increased inflammation associated symptoms after DSS treatment locally and systemically."
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