IndraLab

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SCN5A binds MEF2C. 9 / 9
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"To determine whether MEF2C binds to SCN5A genomic DNA in live cells, we performed ChIP‐qPCR experiments in RL14 cells."
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"To determine whether MEF2C binds to SCN5A genomic DNA in live cells, we performed ChIP-qPCR experiments in RL14 cells."
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"A putative MEF2C binding site located in the promoter region of SCN5A suggests that MEF2C regulates SCN5A by binding to this site. xref Our results showing that MEF2C was associated with the SCN5A gene and that overexpression of MEF2C enhanced the luciferase mRNA expression driven by the WT SCN5A promoter support this idea."
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"The binding of MEF2C and SCN5A WT oligonucleotides could be competed off with unlabeled WT oligonucleotide but not with unlabeled mutant oligonucleotide (Figure  xref A, lanes 4 and 5)."
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"The sequences of the oligonucleotides used in the experiment are shown in Figure  xref B. This result further confirmed that MEF2C bound to the SCN5A gene."
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"The binding of MEF2C and SCN5A WT oligonucleotides could be competed off with unlabeled WT oligonucleotide but not with unlabeled mutant oligonucleotide."
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"The fact revealed by the EMSA experiment that MEF2C was associated with SCN5A sequences confirmed that MEF2C directly interacts with SCN5A gene promoter."
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"MEF2C Bound to the SCN5A Promoter Region."
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"We then tested if the association of MEF2C and the SCN5A gene regulated SCN5A transcription."
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