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OTUB2 activates CTNNB1. 5 / 5
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"These results indicated that OTUB2-regulated expression of CTNNB1 could enhance ZEB1 to promote the invasion and metastasis of iCCA cells.To further investigate the mechanism of CTNNB1 upregulation in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We performed further experiments with the autophagy inhibitor 3-MA, lysosomal inhibitor NH4Cl, and proteasome inhibitor MG132 and found that the autophagy inhibitor and lysosomal inhibitor restored ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, Xu et al. also demonstrated that OTUB2 promotes colorectal cancer growth by regulating β-catenin signaling [38]."
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"showed that inhibiting OTUB2 can suppress the growth of colorectal cancer cells by modulating the β-catenin signaling pathway."
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"Mechanistically , OTUB2 promotes CTNNB1 expression by interacting with the E3 ligase TRAF6 ."
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