IndraLab

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THBS1 binds ITGB3. 14 / 17
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"Furthermore, we confirmed the interaction between TSP-1 and ITGB3 by co-IP experiments, indicating that blocking the binding of TSP-1 to ITGB3 may attenuate renal tubulointerstitial injury.In conclusion, TSP-1 is suggested to mediate renal tubulointerstitial injury in FSGS by binding to its receptor ITGB3."
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"Blocking the binding of TSP-1 to ITGB3 can alleviate renal tubulointerstitial injury and interstitial fibrosis, which may serve as a new therapeutic target for FSGS."
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"In vivo , we identified cyclo-RGDfK as an agent to block the binding of TSP-1 to ITGB3."
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"Therefore, an intervention targeting the binding of TSP-1 to ITGB3 may be a new therapeutic approach."
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"The binding of TSP-1 with its receptor ITGB3 can activate the downstream transforming growth factor β signaling pathway to initiate the development of breast tumors ( xref )."
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"IP assay further showed that the binding between TSP-1 and ITGB3 was enhanced in HK-2 cells after BSA-induced renal tubular epithelial cell injury."
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"In vivo, we identified cyclo-RGDfK as an agent to block the binding of TSP-1 to ITGB3."
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"These results suggested that silencing ITGB3 and using cyclo-RGDfK to prevent the binding between TSP-1 and ITGB3 can attenuate injury in renal tubular epithelial cells."
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"Furthermore, we confirmed the interaction between TSP-1 and ITGB3 by co-IP experiments, indicating that blocking the binding of TSP-1 to ITGB3 may attenuate renal tubulointerstitial injury."
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sparser
"Blocking the binding of TSP-1 to ITGB3 can alleviate renal tubulointerstitial injury and interstitial fibrosis, which may serve as a new therapeutic target for FSGS."
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"Therefore, an intervention targeting the binding of TSP-1 to ITGB3 may be a new therapeutic approach.At present, studies have focused on the role and mechanism of ITGB3 in podocytes, rarely on renal tubular injury."
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"The binding of TSP-1 with its receptor ITGB3 can activate the downstream transforming growth factor β signaling pathway to initiate the development of breast tumors (40)."
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"The TSP-1/ITGB3 complex may also be involved in vascular endothelial lesions in patients with kidney failure (42)."
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"In the in vitro model, our result showed that silencing ITGB3 or treating with ITGB3 inhibitor cyclo-RGDfK prevented the binding between TSP-1 and ITGB3, thus attenuating renal tubular epithelial cell injury."
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