IndraLab

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THBS1 binds ITGB3. 18 / 18
2 1 | 9 6
biogrid
No evidence text available
2478219
sparser
"Moreover, the interaction between THBS1 and ITGB3 in the network diagram suggests that these genes may collaborate in tumor progression through direct protein interactions or signaling pathways [ xref , xref ]."
40911231
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"Furthermore, we confirmed the interaction between TSP-1 and ITGB3 by co-IP experiments, indicating that blocking the binding of TSP-1 to ITGB3 may attenuate renal tubulointerstitial injury.In conclusion, TSP-1 is suggested to mediate renal tubulointerstitial injury in FSGS by binding to its receptor ITGB3."
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reach
"Blocking the binding of TSP-1 to ITGB3 can alleviate renal tubulointerstitial injury and interstitial fibrosis, which may serve as a new therapeutic target for FSGS."
38960036
biogrid
No evidence text available
14963009
hprd
No evidence text available
2478219
sparser
"In vivo , we identified cyclo-RGDfK as an agent to block the binding of TSP-1 to ITGB3."
38960036
sparser
"Therefore, an intervention targeting the binding of TSP-1 to ITGB3 may be a new therapeutic approach."
38960036
sparser
"The binding of TSP-1 with its receptor ITGB3 can activate the downstream transforming growth factor β signaling pathway to initiate the development of breast tumors ( xref )."
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sparser
"Furthermore, we confirmed the interaction between TSP-1 and ITGB3 by co-IP experiments, indicating that blocking the binding of TSP-1 to ITGB3 may attenuate renal tubulointerstitial injury."
38960036
sparser
"Blocking the binding of TSP-1 to ITGB3 can alleviate renal tubulointerstitial injury and interstitial fibrosis, which may serve as a new therapeutic target for FSGS."
38960036
reach
"The binding of TSP-1 with its receptor ITGB3 can activate the downstream transforming growth factor β signaling pathway to initiate the development of breast tumors (40)."
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"The TSP-1/ITGB3 complex may also be involved in vascular endothelial lesions in patients with kidney failure (42)."
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"In the in vitro model, our result showed that silencing ITGB3 or treating with ITGB3 inhibitor cyclo-RGDfK prevented the binding between TSP-1 and ITGB3, thus attenuating renal tubular epithelial cell injury."
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"In vivo, we identified cyclo-RGDfK as an agent to block the binding of TSP-1 to ITGB3."
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"These results suggested that silencing ITGB3 and using cyclo-RGDfK to prevent the binding between TSP-1 and ITGB3 can attenuate injury in renal tubular epithelial cells."
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"IP assay further showed that the binding between TSP-1 and ITGB3 was enhanced in HK-2 cells after BSA-induced renal tubular epithelial cell injury."
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"Therefore, an intervention targeting the binding of TSP-1 to ITGB3 may be a new therapeutic approach.At present, studies have focused on the role and mechanism of ITGB3 in podocytes, rarely on renal tubular injury."
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