IndraLab

Statements

Propranolol inhibits KCNH2. 8 / 8
2 | 6
reach
"The present study demonstrated that propranolol can inhibit hERG channels."
16150441
reach
"Carvedilol (nonselective), propranolol (nonselective) and ICI 118551 (beta (2)-selective) inhibited HERG current in a concentration dependent manner (IC (50) 0.51, 3.9 and 9.2 microM, respectively)."
16314852
reach
"We found that propranolol blocked hERG currents in a concentration dependent manner with an IC50 of 9.9 +/-1.3 microM which is relevant to the predicted plasma level of propranolol in this case report."
16150441
reach
"Propranolol caused a concentration dependent inhibition of HERG current with an IC50 value of 81 microM at -10 mV."
15679475
ctd
No evidence text available
16314852
ctd
No evidence text available
15679475
reach
"Previous studies have shown that hERG, a frequent target of many drugs, is blocked by propranolol with an IC 50 of between 10 muM and 53 muM [XREF_BIBR, XREF_BIBR]."
19481549
reach
"We previously demonstrated that propranolol inhibits hERG potassium channels with an IC 50 of 10muM, which is about 300- to 530-fold higher than its maximum free plasma concentration at therapeutic doses."
18587422