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Propranolol inhibits KCNH2. 10 / 12
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"We previously demonstrated that propranolol inhibits hERG potassium channels with an IC 50 of 10muM, which is about 300- to 530-fold higher than its maximum free plasma concentration at therapeutic doses."
18587422
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"The only exception, propranolol, although used as a negative control has been shown to inhibit hERG at sufficiently high concentrations ( Hanson et al., 2006; Yao et al., 2005 )."
18291682
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"Previous studies have shown that hERG, a frequent target of many drugs, is blocked by propranolol with an IC 50 of between 10 muM and 53 muM [XREF_BIBR, XREF_BIBR]."
19481549
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"As shown in Fig. 1 A and B, hERG tail currents were blocked by propranolol in a concentration-dependent manner with an IC 50 value of 9.9 ± 1.3 μM ( n = 4–8 cells at each concentration)."
16150441
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"Propranolol caused a concentration dependent inhibition of HERG current with an IC50 value of 81 microM at -10 mV."
15679475
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"Carvedilol (nonselective), propranolol (nonselective) and ICI 118551 (beta (2)-selective) inhibited HERG current in a concentration dependent manner (IC (50) 0.51, 3.9 and 9.2 microM, respectively)."
16314852
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"Normalized activation curves are shown in Fig. 2 D. Propranolol caused no significant change in the half-maximal activation voltage ( V 1/2 ) that were − 13 ± 0.1 mV and − 12 ± 0.2 mV ( n = 5) in cont[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16150441
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"We found that propranolol inhibited hERG in a concentration dependent manner with an IC 50 of 9.9 ± 1.3 μM indicating that propranolol has potential to induce QTc prolongation."
16150441
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"The IC 50 value of hERG inhibition by propranolol obtained in this study is about 300–530 fold higher than its human maximum free plasma concentration in humans at therapeutic doses, when a plasma pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16150441
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"In conclusion, the present results demonstrate that propranolol blocks hERG potassium channels."
16150441