IndraLab

Statements

OTUB1 inhibits UBE2. 5 / 12
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"Both E2s can be inhibited by OTUB1 [ xref , xref ]."
35163456
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"In addition, OTUB1 inhibits E2 ubiquitin-conjugating enzymes independent of its enzymatic activity, impeding ubiquitin chain formation [ xref , xref , xref ]."
31299612
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"Thus, the same E2 enzymes that are inhibited by OTUB1 when the E2 is charged with ubiquitin can stimulate OTUB1 when uncharged."
32049508
sparser
"By specifically regulating Lys48-linked ubiquitin and Lys63-linked polyubiquitin, OTUB1 can target and inhibit E2 enzymes, such as UBC13, UBE2D, and UBE2E."
31737118
sparser
"We show that both stimulation of OTUB1 by E2 enzymes and noncatalytic inhibition of E2 enzymes by OTUB1 occur at physiologically relevant concentrations of both partners."
32049508