IndraLab

Statements

OTUB1 inhibits UBE2. 11 / 18
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"OTUB1 inhibits UBC13 (also known as UBE2N) and other E2 enzymes."
25444757
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"In addition, OTUB1 inhibits E2 ubiquitin-conjugating enzymes independent of its enzymatic activity, impeding ubiquitin chain formation [ xref , xref , xref ]."
31299612
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"By specifically regulating Lys48-linked ubiquitin and Lys63-linked polyubiquitin, OTUB1 can target and inhibit E2 enzymes, such as UBC13, UBE2D, and UBE2E."
31737118
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"For instance, OTUB1 inhibits several E2 ubiquitin-conjugating enzymes through protein-protein interactions [42,43,44], and OTULIN interferes with endosomal trafficking by interacting with SNX27, a protein involved in protein trafficking and endocytosis of plasma membrane receptors [45]."
37371581
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"For instance, OTUB1 inhibits several E2 ubiquitin-conjugating enzymes through protein-protein interactions [ xref , xref , xref ], and OTULIN interferes with endosomal trafficking by interacting with SNX27, a protein involved in protein trafficking and endocytosis of plasma membrane receptors [ xref ]."
37371581
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"Moreover, SETD7, a lysine monomethylase, directly interacts with OTUB1 to catalyze the methylation of OTUB1 at Lys 122, disrupting the interaction between OTUB1 and the anti-ferroptosis protein ubiquitin conjugating enzyme E2 N (UBE2N/UBC13) in H1299 lung cancer cells [99]."
38955112
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"We show that both stimulation of OTUB1 by E2 enzymes and noncatalytic inhibition of E2 enzymes by OTUB1 occur at physiologically relevant concentrations of both partners."
32049508
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"OTUB1 inhibits the E2 enzyme, Ubc13/UBE2N plus other E2 conjugating enzymes, independently of its DUB activity by binding directly to the charged E2∼Ub via an N-terminal extension that contains a Ub-binding motif [ xref , xref ]."
38572758
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"OTUB1 inhibits the E2 enzyme, Ubc13/UBE2N plus other E2 conjugating enzymes, independently of its DUB activity by binding directly to the charged E2∼Ub via an N-terminal extension that contains a Ub-binding motif [104,105]."
38572758
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"Thus, the same E2 enzymes that are inhibited by OTUB1 when the E2 is charged with ubiquitin can stimulate OTUB1 when uncharged."
32049508
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"Both E2s can be inhibited by OTUB1 [ xref , xref ]."
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