IndraLab

Statements

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"The observations that MED effectively inhibited LPS induced inflammatory responses in vitro prompted us to investigate whether MED can inhibit LPS induced endotoxin shock in vivo."
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"Consistently, MED suppressed LPS stimulated iNOS protein production in a dose dependent manner (XREF_FIG)."
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"Recently, we have showed that MED could inhibit LPS induced inflammatory responses, ovariectomy induced osteoporosis, and allergic responses in mice [XREF_BIBR - XREF_BIBR]."
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"MED inhibited LPS induced nuclear translocation of nuclear factor (NF)-kappaB (NF-kappaB) p65, IkappaB degradation, IkappaB kinase (IKK) phosphorylation, and the activation of extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38, suggesting that MED blocks the activation of both NF-kappaB and mitogen activated protein kinase (MAPK) pathways."
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"MED significantly inhibited LPS induced production of pro inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon-gamma (INF-gamma), and nitric oxide (NO), whereas it increased anti-inflammatory interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) production in BV2 microglia in a concentration dependent manner without causing cytotoxicity."
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