IndraLab

Statements

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"Recently, we have showed that MED could inhibit LPS induced inflammatory responses, ovariectomy induced osteoporosis, and allergic responses in mice [XREF_BIBR - XREF_BIBR]."
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"MED inhibited LPS induced nuclear translocation of nuclear factor (NF)-kappaB (NF-kappaB) p65, IkappaB degradation, IkappaB kinase (IKK) phosphorylation, and the activation of extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38, suggesting that MED blocks the activation of both NF-kappaB and mitogen activated protein kinase (MAPK) pathways."
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"Consistently, MED suppressed LPS stimulated iNOS protein production in a dose dependent manner (XREF_FIG)."
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"The observations that MED effectively inhibited LPS induced inflammatory responses in vitro prompted us to investigate whether MED can inhibit LPS induced endotoxin shock in vivo."
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