IndraLab

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USP2 decreases the amount of TP53. 5 / 5
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"Therefore, we speculate that USP2 overexpression may lower the ubiquitination levels of p53 by acting on the K305R site of p53 protein and promote the translocation of p53 from the cytoplasm to the nucleus."
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"The WB results revealed that USP2 overexpression inhibited GPX4, SLC7A11 and cytoplasm p53 protein expression, while promoted the nucleus p53 protein expression."
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"Notably, USP2 overexpression promoted p53 expression in the nucleus, while suppressing p53 expression in the cytoplasm (Fig. 4D)."
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"USP2 shows a tendency to bind and deubiquitinate Mdm2 and thus suppress the expression of p53 [152] ."
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"The results demonstrated that USP2 overexpression significantly inhibited p53 ubiquitination levels (Fig. 5A)."
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