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USP13 binds PTEN. 46 / 47
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"To further validate the interaction between USP13 and PTEN, an immunofluorescent confocal microscopic analysis was conducted."
26453058
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"Moreover, purified GST-USP13, but not the GST-GFP control, was able to bind to FLAG-tagged PTEN under cell-free conditions ( xref ), which demonstrated a direct interaction between USP13 and PTEN."
24270891
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"In contrast, USP13 directly binds and deubiquitylates PTEN to suppress tumorigenesis and glycolysis in PTEN-positive breast cancer cells ( xref )."
34688658
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"Additionally, USP13 interacted with the tumor suppressor phosphatase and tensin homolog (PTEN)."
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"In contrast, USP13 directly binds and deubiquitylates PTEN to suppress tumorigenesis and glycolysis in PTEN-positive breast cancer cells (35)."
34688658
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26453058
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"Meanwhile, Qu et al (84) found that the interaction between USP13 and PTEN ultimately inhibited AKT phosphorylation."
40337608
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26453058
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"Mechanistically, USP13 directly bound to phosphatase and tensin homolog (PTEN) and deubiquitinated it, thereby elevating the PTEN expression and improving the MASH phenotype."
39571890
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"PTEN has been identified as an important regulator in RANKL‐induced osteoclastogenesis and participates in the regulation of the phosphorylated inositol 3‐kinase (PI3K)/AKT pathway through the dephosphorylation of phosphatidylinositol 3,4,5‐triphosphate (PIP3). xref , xref AKT directly phosphorylates and activates IKKs to promote IκB degradation, thereby activating the NF‐κB pathway. xref Huang et al. xref found that USP13 directly interacted with PTEN and inhibited its ubiquitination‐related degradation."
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26280536
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"The USP13-PTEN axis may represent a promising molecular target for MASH treatment."
39571890
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"Recently, a new study found that USP13 interacted with PTEN in fibroblasts and regulated PTEN ubiquitination and degradation ( xref )."
28498477
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"Mechanistically, USP13 directly bound to phosphatase and tensin homolog (PTEN) and deubiquitinated it, thereby elevating the PTEN expression and improving the MASH phenotype."
39571890
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"Additionally, USP13 interacted with PTEN and mediated PTEN ubiquitination and degradation in lung fibroblasts."
26453058
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"Considering that loss of PTEN contributed to fibroblasts phenotypic changes and USP13 interacted with PTEN and functioned as a deubiquitylase in epithelial cells, we subsequently sought to determine whether USP13 deficiency is responsible for the low PTEN expression observed in IPF fibroblasts."
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"In line with tyrosine kinase signaling, USP13 interacts and stabilizes the tumor suppressor phosphatase and tensin homolog (PTEN) in lung fibroblasts [75] ( Table 1 )."
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"USP13 interacts with PTEN, stabilizes its expression through deubiquitination and further downregulates AKT signaling to inhibit the proliferation of tumor cells."
38192665
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"To further validate the interaction between USP13 and PTEN, an immunofluorescent confocal microscopic analysis was conducted."
26453058
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"Interestingly, we found that USP13 interacted with PTEN in fibroblasts and regulated PTEN ubiquitination and degradation, supporting the idea that IPF is a cancer like disease."
26453058
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"Meanwhile, Qu et al ( xref ) found that the interaction between USP13 and PTEN ultimately inhibited AKT phosphorylation."
40337608
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"Mechanistically, USP13 bound with PTEN and regulated AKT activation."
37359559
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"USP13 directly binds to and stabilizes PTEN, which alleviates inflammation, apoptosis, and oxidative stress in osteoarthritis ( xref )."
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"Mechanistically, USP13 bound with PTEN and regulated AKT activation."
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26453058
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"Next, we performed a co-immunoprecipitation with whole cell lysates from untreated MRC-5 cells and found an association of PTEN with USP13 (Fig.  xref )."
26453058
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"Co-immunoprecipitation assay was performed to assess the interaction between USP13 and PTEN protein."
31200745
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"Recently, a new study found that USP13 interacted with PTEN in fibroblasts and regulated PTEN ubiquitination and degradation."
28498477
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37646142
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"We sought to determine whether USP13 directly interacts with PTEN and functions as a bona fide PTEN deubiquitinase."
24270891
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"Moreover, purified GST-USP13, but not the GST-GFP control, was able to bind to FLAG tagged PTEN under cell-free conditions (XREF_FIG), which demonstrated a direct interaction between USP13 and PTEN."
24270891
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No evidence text available
33378983
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33378983
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"Mechanistically, USP13 directly interacted with PTEN."
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No evidence text available
33378983
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"Additionally, USP13 interacted with PTEN and mediated PTEN ubiquitination and degradation in lung fibroblasts."
26453058
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"Mechanistically, USP13 directly interacted with PTEN."
33378983
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"In human breast cancer, loss of USP13 is highly associated with loss of PTEN."
24270891
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"We sought to determine whether USP13 directly interacts with PTEN and functions as a bona fide PTEN deubiquitinase."
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