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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1 inhibits EGFR. 2 / 2

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"As our preceding data showed that UCHL1 interacted with and stabilized EGFR (XREF_FIG to XREF_FIG), we next tested whether UCHL1 promotes cardiac hypertrophy by selectively targeting EGFR and the downstream signaling pathway."

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"Knockdown of UCHL1 significantly decreased the half-life of EGFR protein compared with the control group (XREF_FIG), whereas its half-life was markedly increased in Ad-UCHL1-infected NRCMs compared with the Ad-GFP control (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...