IndraLab

Statements

UCHL1 inhibits EGFR. 5 / 5
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"Knockdown of UCHL1 significantly decreased the half-life of EGFR protein compared with the control group (XREF_FIG), whereas its half-life was markedly increased in Ad-UCHL1-infected NRCMs compared with the Ad-GFP control (XREF_FIG)."
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"Immunohistochemistry by Jin et al (88) found that UCH-L1 can inhibit degradation of EGFR, resulting in high expression of P-glycoprotein (P-gp), CD147 and matrix metalloproteinase (MMP) in MDR breast cancer cells."
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"As our preceding data showed that UCHL1 interacted with and stabilized EGFR (XREF_FIG to XREF_FIG), we next tested whether UCHL1 promotes cardiac hypertrophy by selectively targeting EGFR and the downstream signaling pathway."
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"By recognizing and cutting the ubiquitin chains connected with EGFR, UCHL1 reduced the degradation of EGFR through the ubiquitin-proteasome system, thus continuously activating EGFR, Akt and ERK signalling pathways, leading to myocardial hypertrophy (Ref."
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"As a deubiquitinase, UCH-L1 suppresses ERα transcription through the deubiquitinase-mediated stability of epidermal growth factor receptor, which is a corepressor of ERα (10)."
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