IndraLab

Statements

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"Various E3 ubiquitin ligases and deubiquitinases (DUBs), including Pellino 1, Itch, c-Cbl, Cbl-b, GRAIL, and OTUD7B, have been identified to negatively regulate TCR-CD28 signal transduction and preven[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further mechanistic studies reveal that OTUD7B associates with RASGRF1 and PLCE1 to disrupt RAS signaling pathway."
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"Taken together, OTUD7B promotes the proliferation, and autophagy, and inhibits apoptosis of prostate cancer cells via the AKT/mTOR signaling pathway."
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