IndraLab

Statements

CD47 binds ENO1. 17 / 17
| 2 15
sparser
"Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin-mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells."
32226539
sparser
"Together, these results verify that the CD47-ENO1 axis is upregulated in CRC, and the expression of CD47 and ENO1 can be used as predictive biomarkers for the prognosis of CRC patients."
32226539
sparser
"We found that CD47 interacted with ENO1 and inhibit FBXW7-mediated ubiquitylation of ENO1."
32226539
sparser
"Given the clinical and biological significance of the CD47-ENO1 signaling axis, our data demonstrated that CD47 and ENO1 could be used as predictive biomarkers for prognosis and therapeutic targets in CRC."
32226539
sparser
"Since our results clearly showed that ENO1 is the functional mediator of CD47, blocking the CD47-ENO1 axis might be an effective treatment strategy for CD47-high tumors."
32226539
sparser
"Mechanistically, CD47 could physically interact with ENO1 and prevent it from FBXW7-mediated ubiquitination, thereby increasing aerobic glycolysis and the activity of MAPK signaling."
32226539
sparser
"To further elucidate the clinical significance and the interaction between CD47 and ENO1, we subjected the matched TMA for IHC staining of CD47 and ENO1."
32226539
sparser
"According to the previous reports, CD47 interacted with ENO1 and protected it from degradation mediated by ubiquitin, subsequently enhancing the glycolytic activity and phosphorylation of ERK in the CRC cells ( xref )."
34869511
sparser
"The CD47-ENO1 axis also presents as a promising therapeutic target in CRC patients."
32226539
sparser
"Aside from its biological significance, our data also showed that the status of CD47-ENO1 axis might be used for the treatment strategies determination and prognosis prediction in CRC patients."
32226539
reach
"The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP)."
32226539
sparser
"We then sought to find a small molecule which can block the CD47-ENO1 axis to inhibit CRC cell proliferation."
32226539
sparser
"Hu et al. have reported that the overexpression of CD47 in CRC is associated with poor prognosis and metastasis and that the CD47–ENO1 axis may provide a promising insight into the development of targeted therapies for CRC ( xref )."
34367975
sparser
"Functional analyses performed by Hu et al. [ xref ] in CRC demonstrated that CD47 (a molecule which plays a crucial role in the immune escape of tumor cells, proliferation, and formation of metastases) directly interacted with ENO1 and protected it from ubiquitin-mediated degradation, subsequently promoting glycolytic activity and progression of CRC [ xref ]."
35204345
sparser
"Our studies reveal an unconventional role of CD47, suggesting that targeting the CD47-ENO1 axis may provide a novel therapeutic avenue for CRC."
32226539
sparser
"The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP)."
32226539
reach
"Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells."
32226539