IndraLab

Statements

CD47 binds ENO1. 21 / 21
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"Aside from its biological significance, our data also showed that the status of CD47-ENO1 axis might be used for the treatment strategies determination and prognosis prediction in CRC patients."
32226539
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"Mechanistically, CD47 interacts with ENO1, inhibiting its FBXW7-mediated ubiquitination."
39720535
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"The CD47-ENO1 axis also presents as a promising therapeutic target in CRC patients."
32226539
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"Mechanistically, CD47 could physically interact with ENO1 and prevent it from FBXW7-mediated ubiquitination, thereby increasing aerobic glycolysis and the activity of MAPK signaling."
32226539
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"However, ENO1 interacts with CD47 to prevent its ubiquitination and degradation by FBXW7, facilitating glycolysis in CRC cells [80] ."
35031261
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"We found that CD47 interacted with ENO1 and inhibit FBXW7-mediated ubiquitylation of ENO1."
32226539
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"According to the previous reports, CD47 interacted with ENO1 and protected it from degradation mediated by ubiquitin, subsequently enhancing the glycolytic activity and phosphorylation of ERK in the CRC cells ( xref )."
34869511
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"Mechanistically, CD47 competitively interacts with the glycolytic enzyme Enolase 1 (ENO1) to inhibit its binding to FBXW7, an E3 ubiquitin ligase, thereby preventing ENO1 degradation."
39039207
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"Given the clinical and biological significance of the CD47-ENO1 signaling axis, our data demonstrated that CD47 and ENO1 could be used as predictive biomarkers for prognosis and therapeutic targets in CRC."
32226539
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"Functional analyses performed by Hu et al. [ xref ] in CRC demonstrated that CD47 (a molecule which plays a crucial role in the immune escape of tumor cells, proliferation, and formation of metastases) directly interacted with ENO1 and protected it from ubiquitin-mediated degradation, subsequently promoting glycolytic activity and progression of CRC [ xref ]."
35204345
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"Together, these results verify that the CD47-ENO1 axis is upregulated in CRC, and the expression of CD47 and ENO1 can be used as predictive biomarkers for the prognosis of CRC patients."
32226539
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"Hu et al. have reported that the overexpression of CD47 in CRC is associated with poor prognosis and metastasis and that the CD47–ENO1 axis may provide a promising insight into the development of targeted therapies for CRC ( xref )."
34367975
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"The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP)."
32226539
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"Since our results clearly showed that ENO1 is the functional mediator of CD47, blocking the CD47-ENO1 axis might be an effective treatment strategy for CD47-high tumors."
32226539
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"We then sought to find a small molecule which can block the CD47-ENO1 axis to inhibit CRC cell proliferation."
32226539
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"Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin-mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells."
32226539
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"Our studies reveal an unconventional role of CD47, suggesting that targeting the CD47-ENO1 axis may provide a novel therapeutic avenue for CRC."
32226539
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"The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP)."
32226539
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"Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells."
32226539
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"CD47 potentiates the aerobic glycolysis and ERK activity by stabilizing CD47 binding protein ENO1 in colorectal cancer cells (CRCs) and promotes the progression and metastasis of CRCs [85]."
39167629
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"To further elucidate the clinical significance and the interaction between CD47 and ENO1, we subjected the matched TMA for IHC staining of CD47 and ENO1."
32226539