IndraLab

Statements

Dinitrogen activates KCNH2. 3 / 3
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"The introduction of nitrogen in this region of the molecules generally abolished inhibition of the hERG channel, except for the 8-aza isomer 8, in which the degree of hERG inhibition was unaltered com[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The basicity of nitrogen tends to increase hERG potency."
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"The general transformations in XREF_FIG show some changes in the environment of the amine nitrogen can reduce hERG inhibition."
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