IndraLab

Statements

TNFAIP3 inhibits TLR4. 6 / 6
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"Thus the inhibitory effects of A20 on MEKK-1 activation of NF-κB and AP-1 and induction of IL-8 mimicked its effects on TLR-4 suggesting that A20 inhibits TLR-4 at or downstream of MEKK-1."
12659860
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"In a scenario where A20 inhibits TLR-4 at or downstream of MEKK-1, one would predict that the C-terminal region of A20 should also regulate MEKK-1 in a manner similar to its modulation of TLR-4."
12659860
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"High glucose culturing conditions increased TLR4 and NLRP3 proteins, which were also increased by TNFAIP3 siRNA."
35568203
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"Therefore, an increase in TNFAIP3 concentration could potentially decrease both TLR4 and TLR5 signaling, thus modifying the general AEC response to P. aeruginosa.Our results indicate that flagellin induces a transient inflammatory response in the airways that has a positive impact in the lung immune response to P. aeruginosa."
34102087
eidos
"Since TNFAIP3 inhibits TLR4 signaling and consequently suppresses NF-kappaB activation , we examined whether the expression of TNFAIP3 by SKBHT results in the suppression of NF-kappaB activity ."
32256655
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"G-protein-signaling modulator 1 ( GPSM1 ) is upregulated in visceral fat of obese patients with metabolic syndrome, of which it suppresses the transcription of TNF-α-induced protein 3 (TNFAIP3) and st[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36965839