IndraLab

Statements

TNFAIP3 inhibits TLR4. 4 / 4
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reach
"High glucose culturing conditions increased TLR4 and NLRP3 proteins, which were also increased by TNFAIP3 siRNA."
35568203
eidos
"Since TNFAIP3 inhibits TLR4 signaling and consequently suppresses NF-kappaB activation , we examined whether the expression of TNFAIP3 by SKBHT results in the suppression of NF-kappaB activity ."
32256655
sparser
"In a scenario where A20 inhibits TLR-4 at or downstream of MEKK-1, one would predict that the C-terminal region of A20 should also regulate MEKK-1 in a manner similar to its modulation of TLR-4."
12659860
sparser
"Thus the inhibitory effects of A20 on MEKK-1 activation of NF-κB and AP-1 and induction of IL-8 mimicked its effects on TLR-4 suggesting that A20 inhibits TLR-4 at or downstream of MEKK-1."
12659860