IndraLab

Statements

USP6 binds ARF6. 13 / 15
2 | 2 11
sparser
"Via its TRE-2/Bub2/CDC16 (TBC) domain, TRE17 preferentially interacts with ARF6-GDP at tubular endosomes and facilitates its recycling to the PM ( xref )."
30042195
sparser
"It has been found that the TBC domain of TRE17 binds Arf6-GDP ( xref )."
17145964
sparser
"USP6 interacts with Arf6 through its N-terminus Tre2/Bub2/Csc16 (TBC) domain, and depletion of USP6 decreases Arf6 activity [19]."
| PMC
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
sparser
"Based on our observation of internalization of CD147 prior to TRE17-mediated trafficking ( xref ) and the preferential binding of TRE17 to ARF6-GDP ( xref ), the former is more likely, as ARF6 undergoes GTP hydrolysis at SEs via interaction with the ACAP1/2 GAPs ( xref )."
30042195
sparser
"TRE17 associates directly with Arf6 in its GDP- but not GTP-bound state."
15509780
reach
"An interaction between USP6 and Arf6 was identified with a role of USP6 in Arf6 activation by promoting its recruitment to the plasma membrane."
17961905
sparser
"Later on, it was found that TBC domain of USP6 interacts with Arf6, a GTPase member of the Arf family, rather than a Rab."
40348771
sparser
"Second, it was recently reported that the TBC domain of TRE17 binds to Arf6-GDP ( xref )."
17145964
reach
"TRE17 binding to ARF6 increases its activation ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
sparser
"An interaction between USP6 and Arf6 was identified with a role of USP6 in Arf6 activation by promoting its recruitment to the plasma membrane."
17961905
sparser
"TRE17 binding to ARF6 increases its activation xref ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
sparser
"If cargo such as MHC-I or CD98 was directed by infection into EEA1 membranes of a heterotypic SE, then it might be shielded or out of the reach of TRE17, which specifically associates with ARF6-GDP ( xref )."
30042195