IndraLab

Statements

USP6 binds ARF6. 15 / 15
2 | 2 11
sparser
"It has been found that the TBC domain of TRE17 binds Arf6-GDP ( xref )."
17145964
sparser
"USP6 interacts with Arf6 through its N-terminus Tre2/Bub2/Csc16 (TBC) domain, and depletion of USP6 decreases Arf6 activity [19]."
| PMC
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
sparser
"Via its TRE-2/Bub2/CDC16 (TBC) domain, TRE17 preferentially interacts with ARF6-GDP at tubular endosomes and facilitates its recycling to the PM ( xref )."
30042195
sparser
"Based on our observation of internalization of CD147 prior to TRE17-mediated trafficking ( xref ) and the preferential binding of TRE17 to ARF6-GDP ( xref ), the former is more likely, as ARF6 undergoes GTP hydrolysis at SEs via interaction with the ACAP1/2 GAPs ( xref )."
30042195
sparser
"TRE17 associates directly with Arf6 in its GDP- but not GTP-bound state."
15509780
reach
"An interaction between USP6 and Arf6 was identified with a role of USP6 in Arf6 activation by promoting its recruitment to the plasma membrane."
17961905
biogrid
No evidence text available
15509780
biogrid
No evidence text available
15509780
sparser
"Later on, it was found that TBC domain of USP6 interacts with Arf6, a GTPase member of the Arf family, rather than a Rab."
40348771
sparser
"Second, it was recently reported that the TBC domain of TRE17 binds to Arf6-GDP ( xref )."
17145964
reach
"TRE17 binding to ARF6 increases its activation ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
sparser
"An interaction between USP6 and Arf6 was identified with a role of USP6 in Arf6 activation by promoting its recruitment to the plasma membrane."
17961905
sparser
"TRE17 binding to ARF6 increases its activation xref ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
sparser
"If cargo such as MHC-I or CD98 was directed by infection into EEA1 membranes of a heterotypic SE, then it might be shielded or out of the reach of TRE17, which specifically associates with ARF6-GDP ( xref )."
30042195