IndraLab

Statements

PSME3 binds MDM2 and TP53. 4 / 5
1 | 4
sparser
"PA28γ binds to MDM2 and p53, and promotes the MDM2–p53 interaction."
18309296
sparser
"The polymer form of PA28γ interacts with both MDM2 and p53 proteins and facilitates their physical interaction."
18309296
sparser
"We have further defined the regions that are essential for the binding of PA28γ to MDM2 and p53, both of which are within the insert region."
18309296
sparser
"A homopolymer form of PA28γ interacts with both MDM2 and p53 proteins and facilitates their physical interaction, which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53, thus limiting its accumulation and resulting in inhibited apoptosis after DNA damage."
26425675