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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TP53 binds MDM2 and PSME3. 6 / 6
1 | 5
sparser
"A homopolymer form of PA28γ interacts with both MDM2 and p53 proteins and facilitates their physical interaction, which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53, thus limiting its accumulation and resulting in inhibited apoptosis after DNA damage."
hprd
No evidence text available
sparser
"The polymer form of PA28γ interacts with both MDM2 and p53 proteins and facilitates their physical interaction."
sparser
"The polymer form of PA28gamma interacts with both MDM2 and p53 proteins and facilitates their physical interaction."
sparser
"PA28γ binds to MDM2 and p53, and promotes the MDM2p53 interaction."
sparser
"We have further defined the regions that are essential for the binding of PA28γ to MDM2 and p53, both of which are within the insert region."