IndraLab

Statements

TP53 ubiquitinates USP7. 2 / 2
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"At the same time ubiquitination CHIP β-TrCP1 E3 Topors CARP-1 Synoviolin CARP-2 ARF-BP1 E4 Cul4A p300 PirH2 COP1 Mdm2 E6 E6AP E2 UbcH5c UbcH5b Deubiquitination Ub p53 HAUSP E3 MSL-2 E4F1 WWP1 E2 Ubc13 Ubiquitination Ub p53 p53 p53 p53 Degradation Stabilization Modulation of p53 functin Figure 3.  Ubiquitin-ligases that control p53 function and activity."
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"We observed that USP7 efficiently attenuated CHIP-mediated p53 Y220C K48-linked ubiquitination ( xref , F and G )."
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