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USP15 increases the amount of CXCL12. 2 / 2

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"Excessive IFN-gamma production in USP15 deficient mice promotes expression of the immunosuppressive molecule PD-L1 and the chemokine CXCL12, causing accumulation of T-bet + regulatory T cells and CD11b + Gr-1 + myeloid derived suppressor cells at tumor site."

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"The tumor of the Usp15 -/- chimeric mice had upregulated expression of PD-L1 and CXCL12 (XREF_FIG)."

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IndraLab

Statements

USP15 increases the amount of CXCL12. 2 / 2

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