IndraLab

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MiR-26b activates CALM1. 3 / 3
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"MiR-26b targeted CALM1 and affected the expression of CaM at the post-transcriptional level, which likely contributed to the progression of ACI brain injury.KEYWORDS : Acute cerebral infarction, calmodulin, NIHSS, miRNA-26bIntroductionStroke is a leading cause of death and long-term disability worldwide."

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"MiR-26b modulated CALM1 in vitro."

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"MiR-26b downregulates CaM protein expression and affects mRNA degradationTo determine whether miR-26b targets the CALM1 gene and whether miR-26b inhibits CALM1 mRNA translation and (or) degrades mRNA, transfection which has miR-26b mimic or inhibitor plasmids was performed."