IndraLab

Statements

USP18 inhibits cell death. 5 / 5
| 5
reach
"Moreover, we observed that suppression of USP18 in ependymal cells treated with IFN significantly increased cell death, including pyroptosis, and decreased proliferation."
38866307
reach
"In line with this hypothesis, double knockdown of USP18 and DP5, PUMA or Bim protects against USP18 knockdown induced beta cell death."
23152055
reach
"One recent study showed that USP18 inhibition induces pyroptotic cell death (56)."
38959043
reach
"Our results demonstrate that I60N retains deISGylase activity, and the observed accumulation of ISGylated proteins can be decoupled from the loss of catalytic function.Partial impairments in scaffold function by the I60N mutation were correlated with intermediate levels of ISGylation and IFN sensitivity, implicating scaffold function as the primary mechanism by which USP18 loss promotes tumor intrinsic growth arrest and cell death."
38632987
reach
"USP18 inhibition also increased apoptotic cell death by nearly 4-fold in primary rat beta cells after 48h of treatment with IFNalpha (XREF_FIG)."
23152055