IndraLab

Statements

USP4 activates PKM2. 7 / 7
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"These results indicated that USP4 can upregulate PKM2, and the regulatory capability of USP4 is related to its enzyme activity."
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"We already found that USP4 can increase PKM2 expression, and the upregulation of PKM2 by USP4 is associated with its enzymatic activity."
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"Because USP4 upregulates PKM2, we thought that USP4 might be able to change the cell’s proliferation."
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"This result clearly indicates that PKM2 is a mediator for USP4 function in gastric cancer cells.Similarly, the colony formation assay results (Fig 3D–3F) indicated that USP4 promotes gastric cancer proliferation by regulating PKM2."
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"USP4 established its tumor-promoting function (enhancing cell proliferation and the Warburg effect) in gastric cancer cells by upregulating PKM2."
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"USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2."
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"Knockdown of USP4 reduces PKM2 levels and results in a reduction in cell proliferation and the glycolysis rate ."
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