IndraLab

Statements

Metformin inhibits IKBKB. 5 / 5
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"The aim of this study was to (1) determine the ability of metformin to attenuate IKKbeta action, (2) determine whether changes in AMPK activity are associated with changes in IKKbeta action in skeletal muscle, and (3) examine whether changes in AMPK and IKKbeta function are consistent with improved insulin signaling."
20798864
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"Work in endothelial cells and liver has shown that metformin can reduce IKKbeta activity, raising the possibility that activation of AMPK may be a mechanism by which metformin improves insulin sensitivity in skeletal muscle."
20798864
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"Therefore, the aim of this study was to (1) determine whether metformin attenuates IKKbeta activity in skeletal muscle of obese rats, (2) determine whether changes in AMPK are associated with reduced IKKbeta activity in skeletal muscle, and (3) examine whether a decrease in IKKbeta activity coincides with reduced phosphorylation of Ser 307 on IRS1 in skeletal muscle and whether this translates into increased glucose tolerance."
20798864
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"Inasmuch as metformin has been shown to reduce IKKbeta activity in various tissues, IkappaBalpha was measured as an indicator of IKKbeta action."
20798864
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"Metformin and resveratrol blocked JNK and IKKbeta inflammatory signaling and effectively preserved PDE3B activity, presenting another pathway through which to reduce cAMP accumulation."
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