IndraLab

Statements

SCN10A activates TTX-R. 4 / 4
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"The TTX-R resurgent currents are slower than TTX-S resurgent currents, are mediated by Nav1.8, and contribute to membrane excitability of DRG neurons in the presence of TTX."
30803321
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"The TTX-R resurgent currents are mediated by Nav1.8, the dominant TTX-R sodium channel isoform in the small-to-medium diameter DRG neurons."
30803321
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"Nav1.8 sodium channel produces TTX-R current with a high activation threshold and slow inactivation kinetics and contributes to the upstroke of action potentials in small diameter nociceptive DRG neurons (Gold, 1999; Renganathan et al., 2001)."
25903152
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"The TTX-R current produced by NaV1.8 acts as the main contributor to the upstroke of action potentials [51]."
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