IndraLab

Statements

PIO increases the amount of BRCC3. 3 / 3
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reach
"Further in vitro validation via western blot analysis confirmed that PIO upregulated BRCC36 expression and downregulated β-catenin expression in VSMCs under both GM and CM culture conditions (Fig. 6I–L)."
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"Considering the critical role of BRCC36 in β‑catenin function, we next explored the effect of PIO on BRCC36 expression and found that PIO upregulated BRCC36 expression both in vivo and in vitro."
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"Our data preliminarily revealed that PIO upregulated BRCC36 expression in the aortic tissues of CKD mice and VSMCs and further elucidated some of the mechanisms by which pioglitazone affects VC; however, our results did not further confirm that BRCC36 was a direct target of PIO via pull-down assays and proteomic microarrays."
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