IndraLab

Statements

COPS5 activates JNK. 6 / 7
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"In addition, knockdown of JAB1 resulted in reduced activation of NF-κB, which was concordant with accumulation of IκB-α, reduced activation of JNK, and subsequent reduction in the production of MMP1."
16936264
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"MIF inhibits JAB1 and CSN5 mediated AP-1 activity and reduces JNK activity stimulated by JAB1 and CSN5."
11932196
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"NRBP1 regulates the apoptotic pathway by inhibiting Jab1-mediated JNK signaling, which is essential in gene translation and regulation of cellular apoptosis (70–72); it may thus play a key role in suppressing CRC tumorigenesis."
34692549
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"The interaction between MIF and JAB1, mediated by the CXXC motif of MIF, suppresses the activity of JAB1-induced c-Jun N-terminal kinase (JNK) and activates AP-1 [186,187]."
39337534
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"MIF inhibits JAB1-induced JNK and AP-1 activity and JAB1-dependent cell-cycle regulation by increasing p27Kip1 expression through stabilization of p27Kip1 protein."
22959722
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"In addition, MIF interaction with Jab-1 leads to the inhibition of JNK signaling pathways, which are otherwise activated by unbound Jab-1."
31414920