IndraLab

Statements

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"Mechanistically, sustained ER stress up-regulated the deubiquitinating enzyme ubiquitin specific peptidase 14 (USP14), which increased the stability and levels of 3 ',5 '-cyclic monophosphate responsive element binding (CREB) protein (CBP) to enhance glucagon action and hepatic gluconeogenesis."
31594848
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"In conclusion, ER stress induces the upregulation of USP14, which leads to the destruction of glucose homeostasis [XREF_BIBR]."
33546413
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"Studies have shown that sustained ER stress upregulates USP14 from the transcription level through ATF4, thus improving the stability and level of CREB binding protein CBP, enhancing the role of glucagon and hepatic gluconeogenesis."
33546413