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Sevoflurane activates KCNH2. 3 / 3
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"Our results obtained using the ORd model showed that i) sevoflurane more profoundly prolongs APD and QTc interval in LQT2 model in comparison to WT and LQT1 models ( Fig. 2 ), ii) propofol slightly sh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32710951
reach
"Several case reports have shown that sevoflurane induces TdP in genetically identified LQT2 patients ( Saussine et al., 2006 ; Kumakura et al., 2016 ), whereas retrospective observation in LQTS patien[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32710951
reach
"In conclusion, compared with steady-state currents, sevoflurane was more potent in inhibiting the outward tail currents, suggesting that sevoflurane may modulate the HERG channel kinetics in its inactivated state."
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