IndraLab

Statements

USP18 decreases the amount of Interferon. 6 / 6
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"Consequently, USP18 suppression not only enhances expression of canonical IFN-stimulated genes (ISGs), but also activates the expression of a set of atypical ISGs and NF-kappaB target genes, including genes such as Polo like kinase 2 (PLK2), that induce cancer pyroptosis."
36646704
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"Deletion of USP18 enhanced the expression of canonical and non-canonical IFN-stimulated genes (ISGs), and NF-κB target genes, ultimately causing CCP [92] ."
37647772
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"We identified that nuclear USP18 diminishes binding of IFN regulated transcription factors to their corresponding DNA motifs in cooperation with NF-κB. Consequently, the suppression of USP18 not only enhances the expression of canonical IFN-stimulated genes (ISGs) but also activates a set of atypical ISGs and NF-κB target genes that induce cancer pyroptosis."
38799433
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"Depletion of USP18 not only induces the expression of interferon-stimulated genes, but also activates the expression of genes that induce cancer apoptosis and pyroptosis, indicating that USP18 can be used as an effective tool for cancer immunotherapy ."
40325079
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"The authors have demonstrated that: (i) infection of iMphs with HIV-1 induces USP18; (ii) depletion of USP18 with CRISPR/Cas9 increases iMph reactivity to IFNI, the phosphorylation of STAT1 and STAT2, the expression of IFN-stimulated genes and ultimately results in a significant restriction of HIV replication in iMphs."
35725499
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"Inhibiting USP18 enhances the expression of canonical IFN-stimulated genes (ISGs) and activates a subset of non-traditional ISGs and NF-κB target genes, such as PLK2, leading to the induction of cancer pyroptosis [216]."
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