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TNF activates SCN3A. 13 / 14
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"As our previous work has shown that up-regulation of tumor necrosis factor-alpha (TNF-α) in DRG is responsible for the re-expression of Nav1.3 in uninjured DRG neurons following L5 ventral root injury, we investigated whether activation of NF-κB is essential for the up-regulation of Nav1.3 by TNF-α."
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"Furthermore, peri-sciatic exogenous TNF-α, which leads to lasting mechanical allodynia [71], upregulates Nav1.3 and Nav1.8 in DRG in vivo."
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"Furthermore, inhibition of TNF-α synthesis, which prevented neuropathic pain, strongly inhibited the up-regulation of Nav1.3 and Nav1.8."
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"Interestingly, both Nav 1.3 and Nav 1.8 up-regulation was mediated by cytokine TNFα, as was shown by inhibition of TNFα synthesis [26,38]."
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"For example, the proinflammatory cytokine, TNF-α, upregulates Nav1.3 in rat DRG neurons by activating the JNK and p38 MAPK signaling pathways."
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"These data suggest that increased TNF-α may be responsible for up-regulation of Nav1.3 and Nav1.8 in uninjured DRG neurons following nerve injury."
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"Inhibition of TNF-α synthesis or genetic ablation of TNFR1 significantly attenuates the upregulation of Nav1.3 and Nav1.8 in uninjured DRG neurons induced by L5-VRT ( He et al, 2010, Chen et al 2011 )[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, the inhibition of TNF-α synthesis inhibited the up-regulation of Nav1.3 and Nav1.8 and prevented neuropathic pain."
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"In cultured DRG neurons, TNF-α dose-dependently upregulates Nav1.3, Nav1.8 and Nav1.7 ( He et al., 2010; Tamura et al., 2014 )."
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"Also, while IL-1β generally inhibits voltage-gated ion channels to limit excitability, TNF-α can increase the excitability of neurons by enhancing the transcription or Nav1.3 and Nav1.8 upon in vivo."
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"A recent study indicated that L5 ventral root transection produces a TNFα-dependent increase in Nav1.3 at both the mRNA and protein levels in the L4 and L5 DRGs [12]."
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"In cultured DRG neurons, TNF-α upregulates Nav1.3, Nav1.8 and Nav1.7 in a dose-dependent manner ( Chen et al., 2011; He et al., 2010; Tamura et al., 2014 )."
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"Compared to the naïve non-transfected group, TNF-α stimulation induced a significant increase in Nav1.3 at mRNA (Figure 2B, P = 0.0003) and protein level (Figure 2C, P < 0.0001), while a reduction of miR-30b was observed (Figure 2A, P = 0.0007)."
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