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USP35 inhibits RIGI. 3 / 3
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"IFN activates the expression of interferon-stimulated genes (ISGs), which contain ISRE (interferon-stimulated response element) elements in the promoters [ xref ]. we also found that USP35 also inhibited RIG-I or MAVS-induced ISRE-Luc activity (Fig. xref )."
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sparser
"Using the luciferase reporter assay, we found that USP35 inhibits RIG-I and MAVS-mediated IFN-β reporter gene expression."
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reach
"Furthermore, USP35 was found to inhibit RIG-I, but not TBK1-activated IFNβ-Luc expression (Fig. 2B), suggesting that the regulation is at the layer of RIG-I-MAVS."
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