IndraLab

Statements

KCNQ1 inhibits pyraclofos. 3 / 3
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"KCNE1 complexes with KCNQ1 to both slow its voltage stimulated activation and to enhance its open state conductance, resulting in the I Ks current of the cardiac action potential."
22085289
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"The time- and voltage dependent current had biophysical properties typical of cardiac KCNQ1 and KCNE1 current and was almost completely abolished by KCNQ1 blocker chromanol 293B (50 microM)."
19139916
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"Phosphorylation of KCNQ1 decreases the voltage dependence for activation of the channel, increasing the rate of activation and decreasing the rate of deactivation."
31769471