IndraLab

Statements

KCNQ1 inhibits pyraclofos. 5 / 5
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"KCNE1 complexes with KCNQ1 to both slow its voltage stimulated activation and to enhance its open state conductance, resulting in the I Ks current of the cardiac action potential."
22085289
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"KCNE1 regulates the potassium voltage-gated channel subfamily Q member 1 (KCNQ1) channel in a variety of ways : by slowing voltage-stimulated channel activation, increasing conductance, and eliminating channel inactivation."
38306576
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"C28 is another KCNQ1 activator molecule but binds to and stabilizes the voltage sensor domain, thereby decreasing the voltage required for voltage-dependent KCNQ1 activation (Lin et al., 2021)."
38249296
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"Phosphorylation of KCNQ1 decreases the voltage dependence for activation of the channel, increasing the rate of activation and decreasing the rate of deactivation."
31769471
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"The time- and voltage dependent current had biophysical properties typical of cardiac KCNQ1 and KCNE1 current and was almost completely abolished by KCNQ1 blocker chromanol 293B (50 microM)."
19139916