IndraLab

Statements

CDK1 activates USP1. 3 / 3
1 | 2
reach
"To demonstrate that CDK1 also phosphorylates the full-length USP1, individually purified USP1 was treated with CDK1 and incuabled with UAF1 at a 1:1 molar ratio at 37 degreesC for 15 minutes."
23116119
reach
"Thus, cyclin dependent kinase 1 (CDK1)-mediated phosphorylation of S313 during M phase was shown to prolong the stability of USP1 presumably by preventing its degradation by the anaphase promoting complex and cyclosome [XREF_BIBR]."
25744535
signor
"In this study, we show that Ser313 phosphorylation in USP1 is required for its interaction with UAF1 and for the stimulation of USP1's activity. We further demonstrated that CDK1 is responsible for Ser313 phosphorylation, and protein phosphatase treatment of USP1 can lead to inactivation of USP1/UAF1."
23116119