IndraLab

Statements

OTUB1 inhibits PI3K. 2 / 2
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reach
"Besides, when we blocked PI3K/AKT and/or MEK/ERK signaling by its specific inhibitor MK2206 and PD98059, the promotive effect of OTUB1-induced malignant behavior of HCC cells was also significantly reversed (Fig. 6d–q), demonstrating that OTUB1 performed the tumor-enhanced effects by effectively activating the AKT and ERK signaling pathway."
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reach
"The PI3K and AKT pathway integrates the TCR and CD28 and IL-15R signals and is negatively regulated by the DUB Otub1."
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