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USP22 deubiquitinates BMI1. 4 / 5
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"To test whether the endogenous BMI1 is also deubiquitinated by USP22 in glioma cells, we knocked down endogenous USP22 in U251 cells pretreated with CHX and found that endogenous BMI1 also became unstable and degraded rapidly."
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"Our work also discovered PRC1 component Bmi1 deubiquitinated and stabilized by USP22 in glioblastoma cells (data not published)."
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"USP22 interacts with and deubiquitinates BMI1 for post-translational stabilization."
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"3.3 USP22 deubiquitinates BMI1 for protein stabilization."
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