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"These findings indicate that in guinea-pig tracheal smooth muscle : 1) MaxiK channel substantially mediates beta2-adrenoceptor-activated relaxation; 2) both cAMP dependent and -independent mechanisms underlie the functional coupling between beta2-adrenoceptor and MaxiK channel to induce muscle relaxation; and 3) direct regulation of MaxiK channel by Gs operates in cAMP independent coupling between beta2-adrenoceptor and this ion channel."