IndraLab

Statements

USP46 decreases the amount of NRAS-Q61R. 3 / 3
| 3
reach
"In addition, the reduced protein level of NRAS Q61R in USP46-deficient SK-MEL-103 cells could be largely rescued by the reconstitution of USP46 WT, but not the 3 A mutant (Fig. 7h)."
39572526
reach
"Conversely, the depletion of USP46 in SK-MEL-103 cells markedly increased the ubiquitination level of NRAS Q61R (Fig. 4j)."
39572526
reach
"Consistently, the overexpression of USP46 WT dramatically decreased the ubiquitination level of NRAS Q61R, which was markedly abrogated by the depletion or inhibition of CK1δ by PF670462 or Casein kinase 1δ-IN-8 rather than β-catenin inhibitor MSAB (Fig. 7d, e and Supplementary Fig. 10f)."
39572526