IndraLab

Statements

PRDM1 increases the amount of USP22. 5 / 5
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"Mechanistically, PRDM1 enhances USP22 transcription, thus reducing SPI1 protein degradation through deubiquitination, which enhances PD-L1 transcription."
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"It was recently shown that BLIMP1 enhances transcription of USP22 deubiquitinating enzyme leading to decreased degradation of SPI1 transcription factor and subsequent enhanced expression of programmed death ligand 1 (PD-L1), which leads to infiltrated CD8+ T cell exhaustion and memory responses [3]."
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"PRDM1/BLIMP1 regulates USP22 transcription."
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"PRDM1 overexpression only increased the mRNA and protein levels of USP22, whereas PRDM1 knockout decreased the mRNA and protein levels of USP22 (Fig. 4g, h and Supplementary Fig. 4g)."
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"This upregulation may be related to the enhancement of USP22 transcription level by PRDM1, which decreases SPI1 protein degradation through ubiquitination and consequently increases PD-L1 expression [49]."
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